Dealing with complexity of biological systems: from data to models
نویسنده
چکیده
.............................................................................................................................................. 4 INTRODUCTION ...................................................................................................................................... 7 1. THE BIG DATA OF MOLECULAR BIOLOGY ..................................................................................... 9 1.1 Curse of data quantity and of data dimensionality ...................................................................... 9 1.2 Linear and non-linear data dimension reduction ....................................................................... 10 1.3 Blind source separation of biological signals .............................................................................. 11 2. MATHEMATICAL MODELS OF BIOLOGICAL SYSTEMS: COMPLEX OR COMPLICATED? ............... 13 2.1 Asymptotology of reaction networks ......................................................................................... 13 2.2 Mathematical modeling of NFKB and apoptosis signaling ......................................................... 17 2.3 Mathematical modeling of miRNA-mediated translation repression ........................................ 19 3. THE MYSTERIOUS COMPLEX GENOME ....................................................................................... 21 3.1 What we can learn from genome: from genetic code to lifestyle ............................................. 21 3.2 Genome functional fraction estimates ....................................................................................... 24 3.3 Mysteries of cancer genome ...................................................................................................... 25 4. CANCER AS A COMPLEX SYSTEM ................................................................................................ 27 4.1 Formalization of knowledge in cancer biology ........................................................................... 28 4.2 Vertical and horizontal integration of cancer data .................................................................... 29 4.3 Cell fate decisions in cancer cells ............................................................................................... 33 4.4 Exploiting synthetic lethality: a new hope in cancer treatment ................................................ 35 5. CONCLUSION AND PERSPECTIVES .............................................................................................. 39 REFERENCES ......................................................................................................................................... 40
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تاریخ انتشار 2014